Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease-Reference-Cited by-同舟云学术

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Genome-wide analysis reveals characteristics of off-target sites bound by the Cas9 endonuclease

Published:2014-05-18 Issue:7 Volume:32 Page:677-683
ISSN:1087-0156
Container-title:Nature Biotechnology
language:en
Short-container-title:Nat Biotechnol

Author:

Kuscu Cem,Arslan Sevki,Singh Ritambhara,Thorpe Jeremy,Adli Mazhar

Publisher

Springer Science and Business Media LLC

Subject

Biomedical Engineering,Molecular Medicine,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology

Link

http://www.nature.com/articles/nbt.2916.pdf

Reference36 articles.

1. Mali, P. et al. RNA-guided human genome engineering via Cas9. Science 339, 823–826 (2013).

2. Jinek, M. et al. RNA-programmed genome editing in human cells. eLife 2, e00471 (2013).

3. Jiang, W., Bikard, D., Cox, D., Zhang, F. & Marraffini, L.A. RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat. Biotechnol. 31, 233–239 (2013).

4. Cong, L. et al. Multiplex genome engineering using CRISPR/Cas systems. Science 339, 819–823 (2013).

5. Jinek, M. et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337, 816–821 (2012).

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