Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases-Reference-Cited by-同舟云学术

Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases

Published:2021-09-28 Issue:19 Volume:64 Page:14557-14586
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mammoliti Oscar¹^ORCID,Jansen Koen¹,El Bkassiny Sandy¹,Palisse Adeline¹,Triballeau Nicolas²,Bucher Denis²^ORCID,Allart Brigitte¹,Jaunet Alex¹,Tricarico Giovanni¹,De Wachter Maxim¹,Menet Christel¹,Blanc Javier¹,Letfus Vatroslav³,Rupčić Renata³,Šmehil Mario³,Poljak Tanja³,Coornaert Beatrice¹,Sonck Kathleen¹,Duys Inge¹,Waeckel Ludovic²,Lecru Lola²,Marsais Florence²,Jagerschmidt Catherine²,Auberval Marielle²,Pujuguet Philippe²,Oste Line¹,Borgonovi Monica²,Wakselman Emanuelle²,Christophe Thierry¹,Houvenaghel Nicolas¹,Jans Mia¹,Heckmann Bertrand²,Sanière Laurent²,Brys Reginald¹

Affiliation:

1. Galapagos NV, Generaal De Wittelaan L11 A3, 2800 Mechelen, Belgium

2. Galapagos SASU, 102 avenue Gaston Roussel, 93230 Romainville, France

3. Fidelta Ltd., Prilaz Baruna Filipovića 29, ZagrebHR-10000, Croatia

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.1c01066

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1. Idiopathic pulmonary fibrosis