Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors-Reference-Cited by-同舟云学术

Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors

Published:2024-07-19 Issue:15 Volume:67 Page:12534-12552
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gerninghaus Joshua¹²,Zhubi Rezart¹²,Krämer Andreas¹²,Karim Marwah³,Tran Do Hoang Nhu³,Joerger Andreas C.¹²^ORCID,Schreiber Christian¹²,Berger Lena M.¹²^ORCID,Berger Benedict-Tilman¹²^ORCID,Ehret Theresa A.L.¹²,Elson Lewis¹²,Lenz Christopher¹²^ORCID,Saxena Krishna¹²,Müller Susanne¹²^ORCID,Einav Shirit³⁴^ORCID,Knapp Stefan¹²^ORCID,Hanke Thomas¹²^ORCID

Affiliation:

1. Institute of Pharmaceutical Chemistry, Goethe University, Max-von-Laue-Str. 9, Frankfurt am Main 60438, Germany

2. Structural Genomics Consortium (SGC), Buchmann Institute for Life Sciences, Max-von-Laue-Str. 15, Frankfurt am Main 60438, Germany

3. Department of Medicine, Division of Infectious Diseases and Geographic Medicine, and Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California 94305, United States

4. Chan Zuckerberg Biohub, 499 Illinois St, San Francisco, California 94158, United States

Funder

European Commission

Deutschen Konsortium f?r Translationale Krebsforschung

National Institute of Allergy and Infectious Diseases

Deutsche Forschungsgemeinschaft

Congressionally Directed Medical Research Programs

Structural Genomics Consortium

Defense Threat Reduction Agency

Frankfurt Cancer Institute

Publisher

American Chemical Society (ACS)