Novel Isoalantolactone-Based Derivatives as Potent NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization

Author:

Zhao Min1ORCID,Ye Neng2,Liu Ling3,Zhang Rui-Jia2,Li Na2ORCID,Peng Jing2,Cai Xiao-Ying2,Jiang Xue-Qin2,Su Kai-Yue2,Zhang Xin-Lu2,Rao Qian-Ru1,Liu Kong-Jun2,Deng De-Xin2,Peng Ai-Hua2,Tang Ming-Hai2,Chen Li-Juan24,Wu Wen-Shuang5,Ye Hao-Yu2ORCID

Affiliation:

1. Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu 610041, China

2. Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China

3. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China

4. Chengdu Zenitar Biomedical Technology Co., Ltd., Chengdu 610041, China

5. Division of Thyroid Surgery, Department of General Surgery and Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China

Funder

Science and Technology Department of Sichuan Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

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