Novel Isoalantolactone-Based Derivatives as Potent NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization-Reference-Cited by-同舟云学术

Novel Isoalantolactone-Based Derivatives as Potent NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization

Published:2024-04-30 Issue:9 Volume:67 Page:7516-7538
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhao Min¹^ORCID,Ye Neng²,Liu Ling³,Zhang Rui-Jia²,Li Na²^ORCID,Peng Jing²,Cai Xiao-Ying²,Jiang Xue-Qin²,Su Kai-Yue²,Zhang Xin-Lu²,Rao Qian-Ru¹,Liu Kong-Jun²,Deng De-Xin²,Peng Ai-Hua²,Tang Ming-Hai²,Chen Li-Juan²⁴,Wu Wen-Shuang⁵,Ye Hao-Yu²^ORCID

Affiliation:

1. Department of Urology, Institute of Urology (Laboratory of Reconstructive Urology), West China Hospital, Sichuan University, Chengdu 610041, China

2. Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China

3. School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China

4. Chengdu Zenitar Biomedical Technology Co., Ltd., Chengdu 610041, China

5. Division of Thyroid Surgery, Department of General Surgery and Laboratory of Thyroid and Parathyroid Disease, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China

Funder

Science and Technology Department of Sichuan Province

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00357

Reference29 articles.

1. The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

2. Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome

3. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

4. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

5. Specific inhibition of the NLRP3 inflammasome suppresses immune overactivation and alleviates COVID-19 like pathology in mice