Histidine-Covalent Stapled Alpha-Helical Peptides Targeting hMcl-1
Author:
Affiliation:
1. Division of Biomedical Sciences, School of Medicine, University of California Riverside, 900 University Avenue, Riverside, California 92521, United States
2. Cayman Chemical Co., 1180 E. Ellsworth road, Ann Arbor, Michigan 48108, United States
Funder
National Institute of Neurological Disorders and Stroke
University of California, Riverside
Division of Cancer Epidemiology and Genetics
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00277
Reference75 articles.
1. Chemical Synthesis of Hydrocarbon‐Stapled Peptides for Protein Interaction Research and Therapeutic Targeting
2. Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices
3. A Competitive Stapled Peptide Screen Identifies a Selective Small Molecule that Overcomes MCL-1-Dependent Leukemia Cell Survival
4. Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide
5. Iterative optimization yields Mcl-1–targeting stapled peptides with selective cytotoxicity to Mcl-1–dependent cancer cells
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