Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide-Reference-Cited by-同舟云学术

Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide

Published:2015-07-21 Issue:9 Volume:10 Page:2149-2157
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Edwards Amanda L.¹,Wachter Franziska¹,Lammert Margaret¹,Huhn Annissa J.¹,Luccarelli James¹,Bird Gregory H.¹,Walensky Loren D.¹²

Affiliation:

1. Department of Pediatric Oncology, Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, United States

2. Division of Hematology/Oncology, Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts 02215, United States

Funder

National Science Foundation

Alexander von Humboldt-Stiftung

Leukemia and Lymphoma Society

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.5b00214

Reference35 articles.

1. The druggable genome

2. Secondary structure based analysis and classification of biological interfaces: identification of binding motifs in protein–protein interactions

3. Peptide stapling techniques based on different macrocyclisation chemistries

4. Hydrocarbon-Stapled Peptides: Principles, Practice, and Progress

5. A Stapled BID BH3 Helix Directly Binds and Activates BAX

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