2,8-Disubstituted-1,5-naphthyridines as Dual Inhibitors of Plasmodium falciparum Phosphatidylinositol-4-kinase and Hemozoin Formation with In Vivo Efficacy

Author:

Dziwornu Godwin Akpeko1ORCID,Seanego Donald1ORCID,Fienberg Stephen1,Clements Monica1,Ferreira Jasmin1ORCID,Sypu Venkata S.1,Samanta Sauvik1,Bhana Ashlyn D.1,Korkor Constance M.2,Garnie Larnelle F.2,Teixeira Nicole2,Wicht Kathryn J.3ORCID,Taylor Dale4,Olckers Ronald4,Njoroge Mathew4ORCID,Gibhard Liezl4,Salomane Nicolaas5,Wittlin Sergio67ORCID,Mahato Rohit8,Chakraborty Arnish8,Sevilleno Nicole9,Coyle Rachael9,Lee Marcus C. S.9,Godoy Luiz C.10,Pasaje Charisse Flerida10,Niles Jacquin C.10ORCID,Reader Janette11,van der Watt Mariette12,Birkholtz Lyn-Marié11,Bolscher Judith M.13,de Bruijni Marloes H. C.13,Coulson Lauren B.5,Basarab Gregory S.14ORCID,Ghorpade Sandeep R.1ORCID,Chibale Kelly114ORCID

Affiliation:

1. Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa

2. Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa

3. Drug Discovery and Development Centre (H3D), Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa

4. Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory 7925, South Africa

5. Drug Discovery and Development Centre (H3D), Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Observatory, Cape Town 7925, South Africa

6. Swiss Tropical and Public Health Institute, Kreuzstrasse 2, 4123 Allschwil, Switzerland

7. University of Basel, 4001 Basel, Switzerland

8. TCG Lifesciences, Kolkata, 700091, India

9. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton CB10 1SA, U.K.

10. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

11. Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, Pretoria 0028, South Africa

12. Institute for Sustainable Malaria Control, University of Pretoria, Hatfield, Pretoria 0028, South Africa

13. TropIQ Health Sciences, Transistorweg 5, 6534 AT Nijmegen, The Netherlands

14. South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa

Funder

Royal Society

Division of Intramural Research

African Academy of Sciences

Bill and Melinda Gates Foundation

Medicines for Malaria Venture

University of Cape Town

National Research Foundation

South African Medical Research Council

Publisher

American Chemical Society (ACS)

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