Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria-Reference-Cited by-同舟云学术

Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria

Published:2018-06-11 Issue:13 Volume:61 Page:5692-5703
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kandepedu Nishanth¹,Gonzàlez Cabrera Diego¹,Eedubilli Srinivas¹,Taylor Dale²,Brunschwig Christel²,Gibhard Liezl²,Njoroge Mathew²,Lawrence Nina²,Paquet Tanya¹,Eyermann Charles J.¹,Spangenberg Thomas³^ORCID,Basarab Gregory S.¹,Street Leslie J.¹,Chibale Kelly¹⁴^ORCID

Affiliation:

1. Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa

2. Drug Discovery and Development Centre (H3D), DMPK/Pharmacology, University of Cape Town, Observatory 7925, South Africa

3. Merck Global Health Institute, Ares Trading S.A., a subsidiary of Merck KGaA (Darmstadt, Germany), Coinsins 1267, Switzerland

4. South African Medical Research Council, Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa

Funder

University of Cape Town

National Research Foundation

South African Medical Research Council

Merck Global Health Institute

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00648

Reference34 articles.