Design, Synthesis, and Structure–Activity Relationships of Novel Peptide Derivatives of the Severe Acute Respiratory Syndrome-Coronavirus-2 Spike-Protein that Potently Inhibit Nicotinic Acetylcholine Receptors-Reference-Cited by-同舟云学术

Design, Synthesis, and Structure–Activity Relationships of Novel Peptide Derivatives of the Severe Acute Respiratory Syndrome-Coronavirus-2 Spike-Protein that Potently Inhibit Nicotinic Acetylcholine Receptors

Published:2024-05-30 Issue:11 Volume:67 Page:9587-9598
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hone Arik J.¹²^ORCID,Santiago Ulises³,Harvey Peta J.⁴^ORCID,Tekarli Bassel¹,Gajewiak Joanna¹^ORCID,Craik David J.⁴^ORCID,Camacho Carlos J.³,McIntosh J. Michael¹⁵⁶

Affiliation:

1. School of Biological Sciences, University of Utah, Salt Lake City, Utah 84112, United States

2. MIRECC, George E. Whalen Veterans Affairs Medical Center, Salt Lake City, Utah 84148, United States

3. Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, United States

4. Institute for Molecular Bioscience, ARC Centre of Excellence for Innovations in Peptide and Protein Science, The University of Queensland, Brisbane, Queensland 4072, Australia

5. Department of Psychiatry, University of Utah, Salt Lake City, Utah 84112, United States

6. George E. Whalen Veterans Affairs Medical Center, Salt Lake City, Utah 84148, United States

Funder

National Health and Medical Research Council

Australian Research Council

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.4c00735

Reference63 articles.

1. Addendum: A pneumonia outbreak associated with a new coronavirus of probable bat origin

2. Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak

3. A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells

4. The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

5. Omicron and Alpha P680H block SARS-CoV2 spike protein from accessing cholinergic inflammatory pathway via α9-nAChR mitigating the risk of MIS-C