Discovery of a Novel Ketohexokinase Inhibitor with Improved Drug Distribution in Target Tissue for the Treatment of Fructose Metabolic Disease
Author:
Affiliation:
1. TuoJie Biotech (Shanghai) Co., Ltd., Shanghai 201206, P. R. China
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00715
Reference36 articles.
1. The metabolism of fructose in liver. Isolation of fructose-1-phosphate and inorganic pyrophosphate
2. Fructose, weight gain, and the insulin resistance syndrome
3. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
4. Consumption of fructose-sweetened beverages for 10 weeks increases postprandial triacylglycerol and apolipoprotein-B concentrations in overweight and obese women
5. Intermediary metabolism of fructose
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1. Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability;Bioorganic & Medicinal Chemistry Letters;2024-11
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