Going beyond Binary: Rapid Identification of Protein–Protein Interaction Modulators Using a Multifragment Kinetic Target-Guided Synthesis Approach

Author:

Nacheva Katya1,Kulkarni Sameer S.1,Kassu Mintesinot2,Flanigan David13,Monastyrskyi Andrii1,Iyamu Iredia D.12,Doi Kenichiro4,Barber Megan1,Namelikonda Niranjan1,Tipton Jeremiah D.5,Parvatkar Prakash2,Wang Hong-Gang4,Manetsch Roman12678ORCID

Affiliation:

1. Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States

2. Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States

3. Department of Sciences, Hillsborough Community College, Tampa, Florida 33619, United States

4. Department of Pediatrics, Division of Pediatric Hematology and Oncology, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States

5. Proteomics and Mass Spectrometry Core Facility, University of South Florida, Tampa, Florida 33620, United States

6. Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts 02115, United States

7. Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115, United States

8. Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, Massachusetts 02115, United States

Funder

National Institutes of Health

The James and Esther King Biomedical Research Program

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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