Going beyond Binary: Rapid Identification of Protein–Protein Interaction Modulators Using a Multifragment Kinetic Target-Guided Synthesis Approach-Reference-Cited by-同舟云学术

Going beyond Binary: Rapid Identification of Protein–Protein Interaction Modulators Using a Multifragment Kinetic Target-Guided Synthesis Approach

Published:2023-03-31 Issue:7 Volume:66 Page:5196-5207
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Nacheva Katya¹,Kulkarni Sameer S.¹,Kassu Mintesinot²,Flanigan David¹³,Monastyrskyi Andrii¹,Iyamu Iredia D.¹²,Doi Kenichiro⁴,Barber Megan¹,Namelikonda Niranjan¹,Tipton Jeremiah D.⁵,Parvatkar Prakash²,Wang Hong-Gang⁴,Manetsch Roman¹²⁶⁷⁸^ORCID

Affiliation:

1. Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States

2. Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States

3. Department of Sciences, Hillsborough Community College, Tampa, Florida 33619, United States

4. Department of Pediatrics, Division of Pediatric Hematology and Oncology, Penn State College of Medicine, Hershey, Pennsylvania 17033, United States

5. Proteomics and Mass Spectrometry Core Facility, University of South Florida, Tampa, Florida 33620, United States

6. Department of Pharmaceutical Sciences, Northeastern University, Boston, Massachusetts 02115, United States

7. Center for Drug Discovery, Northeastern University, Boston, Massachusetts 02115, United States

8. Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, Massachusetts 02115, United States

Funder

National Institutes of Health

The James and Esther King Biomedical Research Program

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00108

Reference56 articles.

1. Reaching for high-hanging fruit in drug discovery at protein–protein interfaces

2. A matter of life and death

3. BCL-2 in the crosshairs: tipping the balance of life and death

4. The BCL-2 protein family: opposing activities that mediate cell death

5. Inhibition of protein–protein interactions using designed molecules

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