Discovery and Mechanistic Study of Novel <i>Mycobacterium tuberculosis</i> ClpP1P2 Inhibitors-Reference-Cited by-同舟云学术

Discovery and Mechanistic Study of Novel Mycobacterium tuberculosis ClpP1P2 Inhibitors

Published:2023-12-13 Issue:24 Volume:66 Page:16597-16614
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yang Yang¹²,Zhao Ninglin¹,Xu Xin¹,Zhou Yuanzheng¹,Luo Baozhu¹,Zhang Jiangnan¹,Sui Jing¹,Huang Jiasheng¹,Qiu Zhiqiang¹,Zhang Xuelian³,Zeng Jumei⁴^ORCID,Bai Lang¹,Bao Rui¹^ORCID,Luo Youfu¹^ORCID

Affiliation:

1. Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China

2. Capital Institute of Pediatrics, Beijing 100020, PR China

3. School of Life Science, Fudan University, Shanghai 200438, PR China

4. West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China

Funder

State Key Laboratory of Respiratory Disease

National Natural Science Foundation of China

Sichuan Province Science and Technology Support Program

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01054

Reference71 articles.

1. Global Tuberculosis Report 2023; World Health Organization, 2023; Licence: CC BY-NC-SA 3.0 IGO: Geneva. https://www.who.int/publications/i/item/9789240083851.

2. Mechanistic insights into bacterial AAA+ proteases and protein-remodelling machines

3. Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase

4. BacPROTACs mediate targeted protein degradation in bacteria

5. Structure of the drug target ClpC1 unfoldase in action provides insights on antibiotic mechanism of action

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