Novel Amphiphilic PROTAC with Enhanced Pharmacokinetic Properties for ALK Protein Degradation

Author:

Wang Shirui1,Feng Zhanzhan1,Qu Can2,Yu Su1,Zhang Hongjia1,Deng Rui1,Luo Dan3,Pu Chunlan4,Zhang Yan56,Li Rui1ORCID

Affiliation:

1. Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China

2. State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China

3. Department of Pharmacy, West China Hospital of Sichuan University, Chengdu 610031, China

4. Medical Research Center, The Third People’s Hospital of Chengdu, The Affiliated Hospital of Southwest Jiaotong University, The Second Chengdu Hospital Affiliated to Chongqing Medical University, Chengdu 610031, China

5. Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China

6. Lung Cancer Center/Lung Cancer Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China

Funder

National Natural Science Foundation of China

Dazhou Sichuan University project of Dazhou Bureau Science and Technology

Sichuan Science and Technology Program

Publisher

American Chemical Society (ACS)

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