Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity

Author:

Kovada Vadims1,Withers-Martinez Chrislaine2,Bobrovs Raitis1ORCID,Ce̅rule Hele̅na1,Liepins Edgars1,Grinberga Solveiga1,Hackett Fiona2,Collins Christine R.2,Kreicberga Agrita1,Jiménez-Díaz María Belén3,Angulo-Barturen Iñigo3,Rasina Dace1ORCID,Suna Edgars1ORCID,Jaudzems Kristaps1ORCID,Blackman Michael J.24ORCID,Jirgensons Aigars1ORCID

Affiliation:

1. Latvian Institute of Organic Synthesis, Riga LV-1006, Latvia

2. Malaria Biochemistry Laboratory, The Francis Crick Institute, London NW1 1AT, United Kingdom

3. The Art of Discovery SL, Biscay Science and Technology Park, Derio, 48160 Bizkaia, Basque Country, Spain

4. Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London WC1E 7HT, United Kingdom

Funder

Medical Research Council

European Regional Development Fund

Wellcome Trust

Cancer Research UK

LIOS student grant

Latvian Investment and Development agency

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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