Discovery of a Dual Tubulin and Neuropilin-1 (NRP1) Inhibitor with Potent In Vivo Anti-Tumor Activity via Pharmacophore-based Docking Screening, Structure Optimization, and Biological Evaluation-Reference-Cited by-同舟云学术

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Discovery of a Dual Tubulin and Neuropilin-1 (NRP1) Inhibitor with Potent In Vivo Anti-Tumor Activity via Pharmacophore-based Docking Screening, Structure Optimization, and Biological Evaluation

Published:2023-11-24 Issue:23 Volume:66 Page:16187-16200
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zheng Lufeng¹^ORCID,Zou Yunting²,Xie Tianyuan¹,Wu Xiuyuan³,Tan Yuchen³,Mei Shuang²,Geng Yifei²,Chen Shutong²,Xu Shengtao³,Niu Miao-Miao²^ORCID

Affiliation:

1. School of Life Science and Technology, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 211198, China

2. Key Laboratory of Drug Quality Control and Pharmacovigilance, China Pharmaceutical University, Nanjing 211198, China

3. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 211198, China

Funder

China Pharmaceutical University

National Natural Science Foundation of China

Priority Academic Program Development of Jiangsu Higher Education Institutions

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01572

Reference38 articles.

1. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries

2. Metastatic Prostate Cancer

3. Recent advances on anti-angiogenesis receptor tyrosine kinase inhibitors in cancer therapy

4. Angiogenesis as a hallmark of solid tumors - clinical perspectives

5. Dual-Ligand-Modified Liposomes Co-Loaded with Anti-Angiogenic and Chemotherapeutic Drugs for Inhibiting Tumor Angiogenesis and Metastasis

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1. Peptidomimetic inhibitors of the VEGF-A165/NRP-1 complex obtained by modification of the C-terminal arginine;Amino Acids;2024-08-24

2. Design and synthesis of novel 3-amino-5-phenylpyrazole derivatives as tubulin polymerization inhibitors targeting the colchicine-binding site;European Journal of Medicinal Chemistry;2024-03

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