Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes-Reference-Cited by-同舟云学术

Quantitative Attribution of the Protective Effects of Aminosterols against Protein Aggregates to Their Chemical Structures and Ability to Modulate Biological Membranes

Published:2023-07-11 Issue:14 Volume:66 Page:9519-9536
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Errico Silvia¹²^ORCID,Lucchesi Giacomo³,Odino Davide⁴,Osman Enass Youssef¹⁵,Cascella Roberta¹^ORCID,Neri Lorenzo¹,Capitini Claudia⁶⁷⁸,Calamai Martino⁶⁸^ORCID,Bemporad Francesco¹,Cecchi Cristina¹^ORCID,Kinney William A.⁹^ORCID,Barbut Denise⁹,Relini Annalisa⁴^ORCID,Canale Claudio⁴,Caminati Gabriella³^ORCID,Limbocker Ryan¹⁰^ORCID,Vendruscolo Michele²^ORCID,Zasloff Michael⁹¹¹,Chiti Fabrizio¹^ORCID

Affiliation:

1. Department of Experimental and Clinical Biomedical Sciences, Section of Biochemistry, University of Florence, Florence 50134, Italy

2. Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, UK

3. Department of Chemistry “Ugo Schiff” and CSGI, University of Florence, Sesto Fiorentino 50019, Italy

4. Department of Physics, University of Genoa, Genoa 16146, Italy

5. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta 31527, The Arab Republic of Egypt

6. European Laboratory for Non-linear Spectroscopy (LENS), Sesto Fiorentino 50019, Italy

7. Department of Physics and Astronomy, University of Florence, Sesto Fiorentino 50019, Italy

8. National Institute of Optics, National Research Council of Italy (CNR), Florence 50125, Italy

9. Enterin Research Institute Inc., Philadelphia, Pennsylvania 19103, United States

10. Department of Chemistry and Life Science, United States Military Academy, West Point, New York 10996, United States

11. MedStar-Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, District of Columbia 20007, United States

Funder

Regione Toscana

H2020 Research Infrastructures

Universit? degli Studi di Firenze

Ministero dell'Istruzione, dell'Universit? e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00182

Reference46 articles.

1. Protein Misfolding, Amyloid Formation, and Human Disease: A Summary of Progress Over the Last Decade

2. Pathology of Neurodegenerative Diseases

3. Membrane Interactions and Toxicity by Misfolded Protein Oligomers

4. Tuning the ion selectivity of two-pore channels

5. Multistep Inhibition of α-Synuclein Aggregation and Toxicity in Vitro and in Vivo by Trodusquemine

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