Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel–Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers-Reference-Cited by-同舟云学术

Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel–Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers

Published:2023-09-14 Issue:18 Volume:66 Page:12776-12811
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Vu Lan Phuong¹²,Diehl Claudia J.²^ORCID,Casement Ryan²,Bond Adam G.²^ORCID,Steinebach Christian¹^ORCID,Strašek Nika³^ORCID,Bricelj Aleša³,Perdih Andrej³⁴^ORCID,Schnakenburg Gregor⁵,Sosič Izidor³^ORCID,Ciulli Alessio²^ORCID,Gütschow Michael¹^ORCID

Affiliation:

1. Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany

2. Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee, Scotland DD1 5JJ, U.K.

3. Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, SI-1000 Ljubljana, Slovenia

4. National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia

5. Institute of Inorganic Chemistry, University of Bonn, Gerhard-Domagk-Straße 1, D-53121 Bonn, Germany

Funder

Javna Agencija za Raziskovalno Dejavnost RS

Medical Research Scotland

Wellcome Trust

H2020 Marie Sklodowska-Curie Actions

H2020 Health

FP7 Ideas: European Research Council

Biotechnology and Biological Sciences Research Council

Volkswagen Foundation

Bonn International Graduate School of Drug Sciences, University of Bonn

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00434

Reference64 articles.

1. Von Hippel–Lindau disease: insights into oxygen sensing, protein degradation, and cancer

2. Cullin-RING E3 Ubiquitin Ligases: Bridges to Destruction

3. Discovery of small molecule ligands for the von Hippel-Lindau (VHL) E3 ligase and their use as inhibitors and PROTAC degraders

4. Ubiquitin–proteasome pathway and cellular responses to oxidative stress

5. Targeting Cullin–RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation

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