Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel–Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers-Reference-Cited by-同舟云学术

Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel–Lindau E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia-Inducible Factor-1α Stabilizers

Published:2023-09-14 Issue:18 Volume:66 Page:12776-12811
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Vu Lan Phuong¹²,Diehl Claudia J.²^ORCID,Casement Ryan²,Bond Adam G.²^ORCID,Steinebach Christian¹^ORCID,Strašek Nika³^ORCID,Bricelj Aleša³,Perdih Andrej³⁴^ORCID,Schnakenburg Gregor⁵,Sosič Izidor³^ORCID,Ciulli Alessio²^ORCID,Gütschow Michael¹^ORCID

Affiliation:

1. Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, D-53121 Bonn, Germany

2. Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee, Scotland DD1 5JJ, U.K.

3. Faculty of Pharmacy, University of Ljubljana, Aškerčeva 7, SI-1000 Ljubljana, Slovenia

4. National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia

5. Institute of Inorganic Chemistry, University of Bonn, Gerhard-Domagk-Straße 1, D-53121 Bonn, Germany

Funder

Javna Agencija za Raziskovalno Dejavnost RS

Medical Research Scotland

Wellcome Trust

H2020 Marie Sklodowska-Curie Actions

H2020 Health