Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6-Reference-Cited by-同舟云学术

Discovery and Characterization of a Chemical Probe Targeting the Zinc-Finger Ubiquitin-Binding Domain of HDAC6

Published:2023-07-27 Issue:15 Volume:66 Page:10273-10288
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Harding Rachel J.¹²^ORCID,Franzoni Ivan³⁴^ORCID,Mann Mandeep K.¹^ORCID,Szewczyk Magdalena M.¹,Mirabi Bijan³^ORCID,Ferreira de Freitas Renato¹,Owens Dominic D. G.¹,Ackloo Suzanne¹^ORCID,Scheremetjew Alexej³,Juarez-Ornelas Kevin A.³,Sanichar Randy³,Baker Rachel J.³^ORCID,Dank Christian³,Brown Peter J.¹^ORCID,Barsyte-Lovejoy Dalia¹²,Santhakumar Vijayaratnam¹^ORCID,Schapira Matthieu¹²^ORCID,Lautens Mark³^ORCID,Arrowsmith Cheryl H.¹⁵^ORCID

Affiliation:

1. Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada

2. Department of Pharmacology & Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

3. Davenport Research Laboratories, Department of Chemistry, University of Toronto, Toronto, Ontario M5S 3H6, Canada

4. Valence Discovery Inc., 6666 Rue St-Urbain, Suite 200, Montreal, Quebec H2S 3H1, Canada

5. Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 1L7, Canada

Funder

Bayer

Merck KGaA

Genentech

Takeda Pharmaceutical Company

Austrian Science Fund