Discovery of <b>ERD-3111</b> as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader with Strong Antitumor Activity-Reference-Cited by-同舟云学术

Discovery of ERD-3111 as a Potent and Orally Efficacious Estrogen Receptor PROTAC Degrader with Strong Antitumor Activity

Published:2023-08-30 Issue:17 Volume:66 Page:12559-12585
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chen Zhixiang¹,Hu Biao¹^ORCID,Rej Rohan Kalyan¹^ORCID,Wu Dimin¹,Acharyya Ranjan Kumar¹,Wang Mingliang¹,Xu Tianfeng¹^ORCID,Lu Jianfeng¹,Metwally Hoda¹,Wang Yu¹,McEachern Donna¹,Bai Longchuan¹,Gersch Christina L.¹,Wang Meilin²,Zhang Wenjing²,Li Qiuxia²,Wen Bo²,Sun Duxin²^ORCID,Rae James M.¹³⁴,Wang Shaomeng¹³⁵⁴^ORCID

Affiliation:

1. Department of Internal Medicine, Division of Hematology/Oncology, University of Michigan, Ann Arbor, Michigan 48109, United States

2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States

3. Department of Pharmacology, University of Michigan, Ann Arbor, Michigan 48109, United States

4. The Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States

5. Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States

Funder

National Cancer Institute

Oncopia Therapeutics, Inc.

Proteovant Therapeutics, Inc

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01186

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