Electrophilic MiniFrags Revealed Unprecedented Binding Sites for Covalent HDAC8 Inhibitors

Author:

Keeley Aaron B.123,Kopranovic Aleksandra4,Di Lorenzo Vincenzo123ORCID,Ábrányi-Balogh Péter123,Jänsch Niklas4,Lai Linh N.4,Petri László123,Orgován Zoltán123,Pölöske Daniel5,Orlova Anna5,Németh András György123,Desczyk Charlotte4,Imre Tímea16,Bajusz Dávid123ORCID,Moriggl Richard5,Meyer-Almes Franz-Josef4ORCID,Keserü György M.123ORCID

Affiliation:

1. Medicinal Chemistry Research Group, Research Centre for Natural Sciences, Magyar tudósok krt 2, H-1117 Budapest, Hungary

2. Department of Organic Chemistry and Technology, Faculty of Chemical Technology and Biotechnology, Budapest University of Technology and Economics, Müegyetem rkp. 3., H-1111 Budapest, Hungary

3. National Laboratory for Drug Research and Development, H-1117 Budapest, Hungary

4. Department of Chemical Engineering and Biotechnology, University of Applied Sciences Darmstadt, Haardtring 100, 64295 Darmstadt, Germany

5. Institute of Animal Breeding and Genetics, University of Veterinary Medicine, 1210 Vienna, Austria

6. MS Metabolomics Research Group, Research Centre for Natural Sciences, Magyar tudósok krt 2, H-1117 Budapest, Hungary

Funder

Technische Universit?t Darmstadt

Magyar Tudom?nyos Akad?mia

HORIZON EUROPE Marie Sklodowska-Curie Actions

Nemzeti Kutat?si Fejleszt?si ?s Innov?ci?s Hivatal

Hessisches Ministerium f?r Wissenschaft und Kunst

Innov?ci?s ?s Technol?giai Miniszt?rium

State of Hesse

National Laboratory for Drug Research and Development

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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