Design Principles for Fragment Libraries: Maximizing the Value of Learnings from Pharma Fragment-Based Drug Discovery (FBDD) Programs for Use in Academia-Reference-Cited by-同舟云学术

Design Principles for Fragment Libraries: Maximizing the Value of Learnings from Pharma Fragment-Based Drug Discovery (FBDD) Programs for Use in Academia

Published:2016-05-16 Issue:18 Volume:59 Page:8189-8206
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Keserű György M.¹,Erlanson Daniel A.²,Ferenczy György G.¹,Hann Michael M.³,Murray Christopher W.⁴,Pickett Stephen D.³

Affiliation:

1. Research Centre for Natural Sciences, Hungarian Academy of Sciences, Magyar tudósok körútja 2, H-1117, Budapest, Hungary

2. Carmot Therapeutics, Inc. 409 Illinois Street, San Francisco, California 94158, United States

3. Medicines Research Centre, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K.

4. Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, U.K.

Funder

Nemzeti Kutatási, Fejlesztési és Innovációs Hivatal

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.6b00197

Reference145 articles.

1. Pursuing the leadlikeness concept in pharmaceutical research

2. Efficient exploration of chemical space by fragment-based screening

3. The rise of fragment-based drug discovery

4. On the enthalpic preference of fragment binding

5. How Are Fragments Optimized? A Retrospective Analysis of 145 Fragment Optimizations

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