Unsymmetrical Phosphodiesters as GPR84 Antagonists with High Blood Exposure for the Treatment of Lung Inflammation

Author:

Li Shao-Xian12,Wang Si-Wei12,Chen Lin-Hai1ORCID,Zhang Qing134,Lu Dan5,Chen Jing12,Fang You-Chen1,Gu Min1,Xie Xin12354,Nan Fa-Jun1234ORCID

Affiliation:

1. State Key Laboratory of Drug Research, National Center for Drug Screening, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

2. University of Chinese Academy of Sciences, Beijing 100049, China

3. School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China

4. Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, Shandong, China

5. School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210023, China

Funder

Youth Innovation Promotion Association of the Chinese Academy of Sciences

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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