Discovery of Cycloalkyl[<i>c</i>]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors-Reference-Cited by-同舟云学术

Discovery of Cycloalkyl[c]thiophenes as Novel Scaffolds for Hypoxia-Inducible Factor-2α Inhibitors

Published:2023-07-05 Issue:13 Volume:66 Page:8666-8686
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Buchstaller Hans-Peter¹^ORCID,Sala-Hojman Ada¹,Leiendecker Matthias¹,Albers Joachim¹,Anlauf Uwe¹,Berges Nina¹,Dong Liming²,Fuchß Thomas¹,Germann Martina¹,Knehans Tim¹,Krier Mireille¹^ORCID,Lecomte Marc¹,Müller Daniel¹,Müller Sandra R.¹,Leuthner Birgitta¹,Lindemann Ralph¹,Musil Djordje¹,Nowak Mateusz³,Reither Vivian¹,Rettig Corinna¹,Schindler Christina E. M.¹^ORCID,Pakulska Urszula³,Spuck Dieter¹,Wegener Ansgar¹,Zarębski Adrian³

Affiliation:

1. Merck Healthcare KGaA, Frankfurter Strasse 250, 64293 Darmstadt, Germany

2. Pharmaron, Beijing Headquartes, 6 Taihe Road, BDA, 100176 Beijing, China

3. Ryvu Therapeutics S.A., 2 Sternbacha Street, 30-394 Krakow, Poland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00332

Reference57 articles.

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2. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

3. Targeting HIF-1 for cancer therapy

4. Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation

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