Spacial Score─A Comprehensive Topological Indicator for Small-Molecule Complexity-Reference-Cited by-同舟云学术

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Spacial Score─A Comprehensive Topological Indicator for Small-Molecule Complexity

Published:2023-08-31 Issue:18 Volume:66 Page:12739-12750
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Krzyzanowski Adrian¹²,Pahl Axel³,Grigalunas Michael¹^ORCID,Waldmann Herbert¹²^ORCID

Affiliation:

1. Department of Chemical Biology, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, 44227 Dortmund, Germany

2. Faculty of Chemistry, Chemical Biology Technical University Dortmund, Otto-Hahn-Straße 6, 44221 Dortmund, Germany

3. Compound Management and Screening Center, Max Planck Institute of Molecular Physiology, Otto-Hahn-Straße 11, 44227 Dortmund, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00689

Reference55 articles.

1. Chemoinformatics approaches to assess chemical diversity and complexity of small molecules

2. Molecular Complexity and Its Impact on the Probability of Finding Leads for Drug Discovery

3. The maximal affinity of ligands

4. Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

5. Escape from Flatland 2: complexity and promiscuity

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1. Molecular complexity as a driving force for the advancement of organic synthesis;Nature Reviews Chemistry;2024-09-09

2. Analysis of the Change in Molecular Complexity of Reaction Products in Process Development Activities at AstraZeneca Over Time;Organic Process Research & Development;2024-07-26

3. Occurrence of “Natural Selection” in Successful Small Molecule Drug Discovery;Journal of Medicinal Chemistry;2024-07-01

4. Modern Dearomative Enlargement of Heteroaromatic Rings;Synthesis;2024-05-29

5. Measuring Molecular Complexity;ACS Central Science;2024-05-08

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