Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5

Author:

Brusa Irene12,Sondo Elvira3,Pesce Emanuela3,Tomati Valeria3,Gioia Dario2,Falchi Federico12ORCID,Balboni Beatrice12,Ortega Martínez Jose Antonio2,Veronesi Marina4,Romeo Elisa4,Margaroli Natasha4,Recanatini Maurizio1ORCID,Girotto Stefania4ORCID,Pedemonte Nicoletta3,Roberti Marinella1ORCID,Cavalli Andrea125ORCID

Affiliation:

1. Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy

2. Computational & Chemical Biology, Istituto Italiano di Tecnologia, 16163 Genova, Italy

3. UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy

4. Structural Biophysics and Translational Pharmacology Facility, Istituto Italiano di Tecnologia, 16163 Genova, Italy

5. Centre Européen de Calcul Atomique et Moléculaire, EPFL CECAM, 1015 Lousanne, Switzerland

Funder

Ministero della Salute

Cystic Fibrosis Foundation Therapeutics

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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