Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5-Reference-Cited by-同舟云学术

Innovative Strategy toward Mutant CFTR Rescue in Cystic Fibrosis: Design and Synthesis of Thiadiazole Inhibitors of the E3 Ligase RNF5

Published:2023-07-13 Issue:14 Volume:66 Page:9797-9822
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Brusa Irene¹²,Sondo Elvira³,Pesce Emanuela³,Tomati Valeria³,Gioia Dario²,Falchi Federico¹²^ORCID,Balboni Beatrice¹²,Ortega Martínez Jose Antonio²,Veronesi Marina⁴,Romeo Elisa⁴,Margaroli Natasha⁴,Recanatini Maurizio¹^ORCID,Girotto Stefania⁴^ORCID,Pedemonte Nicoletta³,Roberti Marinella¹^ORCID,Cavalli Andrea¹²⁵^ORCID

Affiliation:

1. Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy

2. Computational & Chemical Biology, Istituto Italiano di Tecnologia, 16163 Genova, Italy

3. UOC Genetica Medica, IRCCS Istituto Giannina Gaslini, 16147 Genova, Italy

4. Structural Biophysics and Translational Pharmacology Facility, Istituto Italiano di Tecnologia, 16163 Genova, Italy

5. Centre Européen de Calcul Atomique et Moléculaire, EPFL CECAM, 1015 Lousanne, Switzerland

Funder

Ministero della Salute

Cystic Fibrosis Foundation Therapeutics

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00608

Reference62 articles.

1. The prevalence of cystic fibrosis in the European Union

2. Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

3. Functional architecture of the CFTR chloride channel

4. Role of CFTR in Airway Disease

5. Emerging Therapeutic Approaches for Cystic Fibrosis. From Gene Editing to Personalized Medicine

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