Polymyxins with Potent Antibacterial Activity against Colistin-Resistant Pathogens: Fine-Tuning Hydrophobicity with Unnatural Amino Acids

Author:

Jørgensen Johan Storm1,Mood Elnaz Harifi2,Knap Anne Sofie Holst1,Nielsen Simone Eidnes1,Nielsen Peter E.2ORCID,Żabicka Dorota3,Matias Carina4,Domraceva Ilona5,Björkling Fredrik1ORCID,Franzyk Henrik1ORCID

Affiliation:

1. Center for Peptide-Based Antibiotics, Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 162, DK-2100 Copenhagen Ø, Denmark

2. Center for Peptide-Based Antibiotics, Department of Cellular and Molecular Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, The Panum Building, 3C Blegdamsvej, DK-2200 Copenhagen N, Denmark

3. Department of Epidemiology and Clinical Microbiology, National Medicines Institute, ul. Chełmska 30/34, 00-725 Warsaw, Poland

4. Department of Bacteria, Parasites & Fungi, Statens Serum Institut, Artillerivej 5, DK-2300 Copenhagen S, Denmark

5. Latvian Institute of Organic Synthesis, Aizkraukles 21, 1006 Riga, Latvia

Funder

Novo Nordisk Fonden

Publisher

American Chemical Society (ACS)

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