Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)

Discovery and Structure-Based Design of Inhibitors of the WD Repeat-Containing Protein 5 (WDR5)–MYC Interaction

Published:2023-06-12 Issue:12 Volume:66 Page:8310-8323
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ding Jian¹,Liu Lulu¹,Chiang Ying-Ling¹²^ORCID,Zhao Mengxi²,Liu Hejun²³,Yang Fei¹,Shen Lingling¹,Lin Ying²,Deng Huiwen²,Gao Jingyan²,Sage David R.¹,West Laura¹,Llamas Luis A.¹,Hao Xin²,Kawatkar Sameer¹,Li En²,Jain Rishi K.¹,Tallarico John A.¹,Canham Stephen M.¹^ORCID,Wang He¹²^ORCID

Affiliation:

1. Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States

2. Novartis Institutes for BioMedical Research, Shanghai 201203, China

3. Novartis Institutes for BioMedical Research, San Diego, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00787

Reference35 articles.

1. Two sides of the Myc-induced DNA damage response: from tumor suppression to tumor maintenance

2. Mammalian MYC Proteins and Cancer

3. Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

4. Proteins of the Myc Network: Essential Regulators of Cell Growth and Differentiation

5. MYC on the Path to Cancer

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