Discovery of 5-Phenylpyrazolopyrimidinone Analogs as Potent Antitrypanosomal Agents with In Vivo Efficacy-Reference-Cited by-同舟云学术

Discovery of 5-Phenylpyrazolopyrimidinone Analogs as Potent Antitrypanosomal Agents with In Vivo Efficacy

Published:2023-07-20 Issue:15 Volume:66 Page:10252-10264
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zheng Yang¹^ORCID,van den Kerkhof Magali²,van der Meer Tiffany¹,Gul Sheraz³⁴,Kuzikov Maria³⁴,Ellinger Bernhard³⁴,de Esch Iwan J. P.¹^ORCID,Siderius Marco¹,Matheeussen An²,Maes Louis²,Sterk Geert Jan¹,Caljon Guy²,Leurs Rob¹^ORCID

Affiliation:

1. Amsterdam Institute for Molecules, Medicines and Systems, Division of Medicinal Chemistry, Faculty of Science, Vrije Universiteit Amsterdam, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands

2. Laboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium

3. Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, 22525 Hamburg, Germany

4. Fraunhofer Cluster of Excellence for Immune-Mediated Diseases CIMD, 22525 Hamburg, Germany

Funder

FP7 Health

European Cooperation in Science and Technology

China Scholarship Council

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c00161

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3. Human African trypanosomiasis

4. WHO. WHO HAT 2020. https://www.who.int/news-room/fact-sheets/detail/trypanosomiasis-human-african-(sleeping-sickness) (accessed 04 18, 2022).

5. New WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: substantial changes for clinical practice

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