Uncovering PROTAC Sensitivity and Efficacy by Multidimensional Proteome Profiling: A Case for STAT3

Author:

Suo Yuying12,Du Daohai3,Chen Chao456,Zhu Hongwen2,Wang Xiongjun7ORCID,Song Nixue2,Lu Dayun2,Yang Yaxi1856,Li Jiacheng3,Wang Jun3ORCID,Luo Zhongyuan3,Zhou Bing1856ORCID,Luo Cheng893ORCID,Zhou Hu182ORCID

Affiliation:

1. University of Chinese Academy of Sciences, NO.19A Yuquan Road, Beijing 100049, P. R. China

2. Department of Analytical Chemistry, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences, Shanghai 201203, China

3. Drug Discovery and Design Center, the Center for Chemical Biology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China

4. Department of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China

5. Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai, Shandong 264117, China

6. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China

7. Precise Genome Engineering Center, School of Life Sciences, Guangzhou University, Guangzhou 510006, China

8. School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China

9. Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528437, China

Funder

Natural Science Foundation of Shanghai Municipality

Guangdong Provincial Department of Science and Technology

National Key Research and Development Program of China

National Health Commission of the People's Republic of China

Science and Technology Commission of Shanghai Municipality

National Natural Science Foundation of China

Program of Shanghai Academic Research Leader

National Centre for Protein Science Shanghai

Publisher

American Chemical Society (ACS)

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