Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood-Reference-Cited by-同舟云学术

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Design of a Supersoft Topical JAK Inhibitor, Which Is Effective in Human Skin but Rapidly Deactivated in Blood

Published:2023-10-31 Issue:21 Volume:66 Page:15042-15053
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Thoma Gebhard¹^ORCID,Decoret Odile¹,Vangrevelinghe Eric¹,Trunzer Markus²,Decker Andrea³,Orjuela Leon Anette⁴,Beerli Christian⁴,Bruno Sandro⁴,Hauchard Alice⁴,Paulat Guido⁴,Zerwes Hans-Guenter⁴,Hacini-Rachinel Feriel⁴

Affiliation:

1. Global Discovery Chemistry, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland

2. PK Sciences, Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland

3. Chemical and Pharmaceutical Profiling, Global Drug Development, Novartis Pharma AG, 4002 Basel, Switzerland

4. Immunology Disease Area, Novartis Institutes for Biomedical Research, 4002 Basel, Switzerland

Funder

Novartis

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01735

Reference18 articles.

1. The JAK/STAT signaling pathway: from bench to clinic

2. JAK/STAT inhibitors for the treatment of atopic dermatitis

3. JAK inhibitors in dermatology: The promise of a new drug class

4. Growing evidence of the safety of JAK inhibitors in patients with rheumatoid arthritis

5. Topical tofacitinib for atopic dermatitis: a phase II a randomized trial

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