Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library-Reference-Cited by-同舟云学术

Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library

Published:2024-01-29 Issue:3 Volume:67 Page:2049-2065
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rowley Ann M.¹^ORCID,Yao Gang²,Andrews Logan³^ORCID,Bedermann Aaron¹^ORCID,Biddulph Ross⁴,Bingham Ryan⁴,Brady Jennifer J.³^ORCID,Buxton Rachel⁴,Cecconie Ted¹,Cooper Rona¹,Csakai Adam²,Gao Enoch N.¹,Grenier-Davies Melissa C.²,Lawler Meghan²,Lian Yiqian¹^ORCID,Macina Justyna⁴,Macphee Colin⁴,Marcaurelle Lisa²,Martin John¹,McCormick Patricia¹,Pindoria Rekha⁴,Rauch Martin¹,Rocque Warren¹,Shen Yingnian¹,Shewchuk Lisa M.¹,Squire Michael¹,Stebbeds Will⁴,Tear Westley²,Wang Xin³^ORCID,Ward Paris¹,Xiao Shouhua³

Affiliation:

1. GSK, 1250 South Collegeville Road, Collegeville, Pennsylvania 19426, United States

2. GSK, Encoded Library Technologies, NCE Molecular Discovery, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States

3. 23andMe Inc, Therapeutics, 349 Oyster Point Boulevard, South San Francisco, California 94080, United States

4. GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, Hertfordshire, U.K.

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01562

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4. Various subtypes of phosphodiesterase inhibitors differentially regulate pulmonary vein and sinoatrial node electrical activities

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