Therapeutic targeting of 3′,5′-cyclic nucleotide phosphodiesterases: inhibition and beyond
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/s41573-019-0033-4.pdf
Reference353 articles.
1. Maurice, D. H. et al. Advances in targeting cyclic nucleotide phosphodiesterases. Nat. Rev. Drug Discov. 13, 290–314 (2014).
2. Schneider, E. H. & Seifert, R. Inactivation of non-canonical cyclic nucleotides: hydrolysis and transport. Handb. Exp. Pharmacol. 238, 169–205 (2017). This work is a helpful review of the role PDEs play in regulating non-canonical cyclic nucleotides.
3. Herbst, S. et al. Transmembrane redox control and proteolysis of PdeC, a novel type of c-di-GMP phosphodiesterase. EMBO J. 37, e97825 (2018).
4. Seifert, R. cCMP and cUMP across the tree of life: from cCMP and cUMP generators to cCMP- and cUMP-regulated cell functions. Handb. Exp. Pharmacol. 238, 3–23 (2017).
5. Patel, N. S. et al. Identification of new PDE9A isoforms and how their expression and subcellular compartmentalization in the brain change across the life span. Neurobiol. Aging 65, 217–234 (2018). This study is a first report showing that the subcellular compartmentalization of a PDE family differs depending on the specific isoform, age and tissue investigated.
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