Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant-Reference-Cited by-同舟云学术

Structure-Based Optimization of N-Substituted Oseltamivir Derivatives as Potent Anti-Influenza A Virus Agents with Significantly Improved Potency against Oseltamivir-Resistant N1-H274Y Variant

Published:2018-10-26 Issue:22 Volume:61 Page:9976-9999
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Zhang Jian¹^ORCID,Murugan Natarajan Arul²,Tian Ye¹³,Bertagnin Chiara⁴,Fang Zengjun¹⁵,Kang Dongwei¹^ORCID,Kong Xiujie¹,Jia Haiyong¹,Sun Zhuosen¹,Jia Ruifang¹,Gao Ping¹,Poongavanam Vasanthanathan⁶^ORCID,Loregian Arianna⁴,Xu Wenfang¹,Ma Xiuli⁷,Ding Xiao¹,Huang Bing⁷,Zhan Peng¹^ORCID,Liu Xinyong¹

Affiliation:

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P. R. China

2. Division of Theoretical Chemistry and Biology, School of Biotechnology, KTH Royal Institute of Technology, S-106 91 Stockholm, Sweden

3. Key Laboratory for Experimental Teratology of Ministry of Education, Key Laboratory of Infection and Immunity of Shandong Province, Department of Immunology, School of Basic Medical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong P. R. China

4. Department of Molecular Medicine, University of Padova, Via Gabelli 63, 35121 Padova, Italy

5. The Second Hospital of Shandong University, No. 247 Beiyuan Avenue, 250033 Jinan, China

6. Department of Physics, Chemistry, and Pharmacy, University of Southern Denmark, DK-5230 Odense M, Denmark

7. Institute of Poultry Science, Shandong Academy of Agricultural Sciences, 1, Jiaoxiao Road, 250023 Jinan, Shandong, P. R. China

Funder

Shandong Province

Associazione Italiana per la Ricerca sul Cancro

Shandong University

National Natural Science Foundation of China

Universit? degli Studi di Padova

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01065

Reference68 articles.

1. Serendipitous Discovery of a Potent Influenza Virus A Neuraminidase Inhibitor

2. Emergence and pandemic potential of swine-origin H1N1 influenza virus

3. The avian and mammalian host range of highly pathogenic avian H5N1 influenza

4. Design of Multi-Binding-Site Inhibitors, Ligand Efficiency, and Consensus Screening of Avian Influenza H5N1 Wild-Type Neuraminidase and of the Oseltamivir-Resistant H274Y Variant

5. Virtual screening pipeline and ligand modelling for H5N1 neuraminidase

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