Discovery of a Potent (4R,5S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling-Reference-Cited by-同舟云学术

Discovery of a Potent (4R,5S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling

Published:2018-03-29 Issue:8 Volume:61 Page:3641-3659
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Chen Huifen^ORCID,Volgraf Matthew,Do Steven,Kolesnikov Aleksandr,Shore Daniel G.,Verma Vishal A.,Villemure Elisia,Wang Lan,Chen Yong¹,Hu Baihua¹,Lu Ai-Jun¹,Wu Guosheng¹,Xu Xiaofeng¹,Yuen Po-wai¹,Zhang Yamin¹,Erickson Shawn D.²,Dahl Martin²,Brotherton-Pleiss Christine²,Tay Suzanne,Ly Justin Q.,Murray Lesley J.,Chen Jun,Amm Desiree³,Lange Wienke³,Hackos David H.,Reese Rebecca M.,Shields Shannon D.,Lyssikatos Joseph P.,Safina Brian S.,Estrada Anthony A.

Affiliation:

1. Pharmaron-Beijing Co. Ltd., 6 Taihe Road, BDA, Beijing 100176, P. R. China

2. Small Molecule Research, Pharmaceutical Research and Early Drug Development, Hoffmann-La Roche Inc., 340 Kingsland Street, Nutley, New Jersey 07110, United States

3. Ion Channels Group, Evotec AG, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00117

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1. TRP Channels and Pain

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