Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors-Reference-Cited by-同舟云学术

Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors

Published:2018-08-20 Issue:17 Volume:61 Page:7785-7795
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Liu Shuai¹,Yosief Hailemichael O.¹,Dai Lingling²,Huang He³,Dhawan Gagan¹⁴,Zhang Xiaofeng¹,Muthengi Alex M.¹,Roberts Justin,Buckley Dennis L.,Perry Jennifer A.,Wu Lei,Bradner James E.⁵^ORCID,Qi Jun⁶^ORCID,Zhang Wei¹^ORCID

Affiliation:

1. Department of Chemistry, University of Massachusetts—Boston, Boston, Massachusetts 02125, United States

2. Phase I Clinical Trial Center & Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China

3. Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States

4. Department of Biomedical Science, Acharya Narendra Dev College, University of Delhi, New Delhi 110019, India

5. Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139, United States

6. Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, United States

Funder

National Cancer Institute

National Institute of Child Health and Human Development

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00765

Reference42 articles.

1. Beating the odds: BETs in disease

2. BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism

3. BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

4. Selective inhibition of CD4+ T-cell cytokine production and autoimmunity by BET protein and c-Myc inhibitors

5. Bromodomains and Their Pharmacological Inhibitors

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