Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated-Reference-Cited by-同舟云学术

Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated

Published:2019-04-09 Issue:9 Volume:62 Page:4426-4443
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Géraldy Magalie,Morgen Michael,Sehr Peter¹,Steimbach Raphael R.²,Moi Davide,Ridinger Johannes²³⁴,Oehme Ina³⁵,Witt Olaf³⁴⁵,Malz Mona,Nogueira Mauro S.⁶,Koch Oliver⁶^ORCID,Gunkel Nikolas⁵,Miller Aubry K.⁵^ORCID

Affiliation:

1. Chemical Biology Core Facility, European Molecular Biology Laboratory, 69117 Heidelberg, Germany

2. Biosciences Faculty, University of Heidelberg, 69120 Heidelberg, Germany

3. Hopp Children’s Cancer Center Heidelberg (KiTZ), 69120 Heidelberg, Germany

4. Department of Pediatric Oncology, Hematology and Immunology, University Hospital Heidelberg, 69120 Heidelberg, Germany

5. German Cancer Consortium (DKTK), 69120 Heidelberg, Germany

6. Faculty of Chemistry and Chemical Biology, TU Dortmund University, 44227 Dortmund, Germany

Funder

Bundesministerium f?r Bildung und Forschung

Helmholtz-Gemeinschaft

German Cancer Consortium

Mercator Research Center Ruhr

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01936

Reference49 articles.

1. A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

2. Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug

3. Histone Deacetylase 11 Is a Fatty-Acid Deacylase

4. Histone deacetylase 10 structure and molecular function as a polyamine deacetylase

5. HDAC8 Catalyzes the Hydrolysis of Long Chain Fatty Acyl Lysine

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