Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development-Reference-Cited by-同舟云学术

Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development

Published:2018-12-19 Issue:2 Volume:62 Page:665-687
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Bachovchin Kelly A.¹,Sharma Amrita²,Bag Seema¹,Klug Dana M.¹,Schneider Katherine M.¹,Singh Baljinder¹^ORCID,Jalani Hitesh B.¹^ORCID,Buskes Melissa J.¹,Mehta Naimee¹,Tanghe Scott³,Momper Jeremiah D.⁴,Sciotti Richard J.⁵,Rodriguez Ana³,Mensa-Wilmot Kojo²,Pollastri Michael P.¹^ORCID,Ferrins Lori¹^ORCID

Affiliation:

1. Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts 02115, United States

2. Department of Cellular Biology, Center for Tropical and Emerging Global Diseases, University of Georgia, Athens, Georgia 30602, United States

3. Department of Microbiology and Anti-Infectives Screening Core, New York University School of Medicine, 430 East 29th Street, New York, New York 10016, United States

4. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, United States

5. Experimental Therapeutics, Walter Reed Army Institute for Research, 2460 Linden Lane, Silver Spring, Maryland 20910, United States

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01365

Reference42 articles.

1. Kinase Scaffold Repurposing for Neglected Disease Drug Discovery: Discovery of an Efficacious, Lapatanib-Derived Lead Compound for Trypanosomiasis

2. Human African trypanosomiasis

3. Human African trypanosomiasis

4. World Health Organization. Department of Control of Neglected Tropical Diseases, Human African Trypanosomiasis. http://whqlibdoc.who.int/hq/2001/WHO_CDS_CSR_EPH_2001.3.pdf (accessed November 13, 2018).

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