Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis-Reference-Cited by-同舟云学术

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Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis

Published:2018-08-22 Issue:17 Volume:61 Page:7862-7876
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Miller Mark¹,Pal Arindom¹,Albusairi Wabel¹,Joo Hyun¹,Pappas Beverly¹,Haque Tuhin Md Tariqul¹,Liang Dengpan¹,Jampala Raghavendra¹,Liu Fang¹,Khan Jared¹,Faaij Marjon¹,Park Miki¹,Chan William¹,Graef Isabella²,Zamboni Robert³,Kumar Neil³,Fox Jonathan³,Sinha Uma³,Alhamadsheh Mamoun¹^ORCID

Affiliation:

1. Department of Pharmaceutics & Medicinal Chemistry, University of the Pacific, Stockton, California 95211, United States

2. Department of Pathology, Stanford University, Stanford, California 94305, United States

3. Eidos Therapeutics, Inc., San Francisco, California 94101, United States

Funder

National Institute of General Medical Sciences

Eidos Therapeutics

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00817

Reference39 articles.

1. The Systemic Amyloidoses

2. Native State Kinetic Stabilization as a Strategy To Ameliorate Protein Misfolding Diseases: A Focus on the Transthyretin Amyloidoses

3. Transthyretin Cardiac Amyloidosis in Older Americans

4. Transthyretin Cardiac Amyloidosis: Pathogenesis, Treatments, and Emerging Role in Heart Failure with Preserved Ejection Fraction

5. Transthyretin V122I (pV142I)* cardiac amyloidosis: an age-dependent autosomal dominant cardiomyopathy too common to be overlooked as a cause of significant heart disease in elderly African Americans

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1. Native State Stabilization of Amyloidogenic Proteins by Kinetic Stabilizers: Inhibition of Protein Aggregation and Clinical Relevance;ChemMedChem;2024-08-23

2. Transthyretin Stabilizer Therapy in Patients With Transthyretin Amyloid Cardiomyopathy: A Systematic Review and Meta-Analysis;American Journal of Therapeutics;2024-08-07

3. Development of Benziodarone Analogues with Enhanced Potency for Selective Binding to Transthyretin in Human Plasma;Journal of Medicinal Chemistry;2024-04-26

4. Treatment of transthyretin cardiac amyloidosis;Current Opinion in Cardiology;2024-04-19

5. Efficacy and Safety of Acoramidis in Transthyretin Amyloid Cardiomyopathy;New England Journal of Medicine;2024-01-11

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