A Cinchona Alkaloid Antibiotic That Appears To Target ATP Synthase in Streptococcus pneumoniae

Author:

Wang Xu,Zeng Yuna1,Sheng Li,Larson Peter2,Liu Xue1,Zou Xiaowen,Wang Shufang,Guo Kaijing,Ma Chen,Zhang Gang,Cui Huaqing,Ferguson David M.2ORCID,Li Yan,Zhang Jingren1,Aldrich Courtney C.2ORCID

Affiliation:

1. Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing 100084, People’s Republic of China

2. Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, United States

Funder

Peking Union Medical College Hospital

State Key Laboratory of Bioactive Substance and Function of Natural Medicines

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference74 articles.

1. Centers for Disease Control and Prevention. Antibiotic Resistance Threats in the United States, 2013 https://www.cdc.gov/drugresistance/threat-report-2013/ (accessed Aug 20, 2018).

2. http://www.who.int/mediacentre/factsheets/fs331/en/ (accessed Aug 20, 2018).

3. Emergence of Multidrug-Resistant Pneumococcal Serotype 35B among Children in the United States

4. Multidrug Resistance in Non-PCV13 Serotypes ofStreptococcus pneumoniaein Northern Japan, 2014

5. Changes in Pneumococcal Serotypes and Antimicrobial Resistance after Introduction of the 13-Valent Conjugate Vaccine in the United States

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