Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing-Reference-Cited by-同舟云学术

Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing

Published:2019-01-15 Issue:3 Volume:62 Page:1362-1372
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Abdelsamie Ahmed S.¹²^ORCID,Herath Steven,Biskupek Yannik,Börger Carsten³,Siebenbürger Lorenz³,Salah Mohamed⁴^ORCID,Scheuer Claudia,Marchais-Oberwinkler Sandrine⁵^ORCID,Frotscher Martin⁴^ORCID,Pohlemann Tim,Menger Michael D.,Hartmann Rolf W.⁴⁶^ORCID,Laschke Matthias W.,van Koppen Chris J.¹⁴^ORCID

Affiliation:

1. ElexoPharm GmbH, Im Stadtwald, Building A1.2, 66123 Saarbrücken, Germany

2. Chemistry of Natural and Microbial Products Department, National Research Centre, Dokki, 12622 Cairo, Egypt

3. PharmBioTec GmbH, 66123 Saarbrücken, Germany

4. Department of Pharmaceutical and Medicinal Chemistry, Saarland University, 66123 Saarbrücken, Germany

5. Institute of Pharmaceutical Chemistry, Philipps-University, 35032 Marburg, Germany

6. Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123 Saarbrücken, Germany

Funder

Bundesministerium für Bildung und Forschung

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01493

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2. 11β-HSD1 inhibition ameliorates metabolic syndrome and prevents progression of atherosclerosis in mice

3. Novel Hydroxysteroid (17β) Dehydrogenase 1 Inhibitors Reverse Estrogen-Induced Endometrial Hyperplasia in Transgenic Mice

4. Teriparatide for acceleration of fracture repair in humans: A prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures

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