Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Characterization of Orally Active 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors Targeting the Prevention of Osteoporosis

Published:2019-07-25 Issue:15 Volume:62 Page:7289-7301
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Abdelsamie Ahmed S.¹²^ORCID,Salah Mohamed³^ORCID,Siebenbürger Lorenz⁴,Merabet Ahmed¹⁵,Scheuer Claudia⁶,Frotscher Martin³^ORCID,Müller Sebastian T.⁷,Zierau Oliver⁷,Vollmer Günter⁷,Menger Michael D.⁶,Laschke Matthias W.⁶,van Koppen Chris J.¹³^ORCID,Marchais-Oberwinkler Sandrine⁵^ORCID,Hartmann Rolf W.³⁸^ORCID

Affiliation:

1. ElexoPharm GmbH, Im Stadtwald, Building A1.2, 66123 Saarbrücken, Germany

2. Chemistry of Natural and Microbial Products Department, National Research Centre, Dokki, 12622 Cairo, Egypt

3. Department of Pharmaceutical and Medicinal Chemistry, Saarland University, 66123 Saarbrücken, Germany

4. PharmBioTec GmbH, 66123 Saarbrücken, Germany

5. Institute of Pharmaceutical Chemistry, Philipps-University, 35032 Marburg, Germany

6. Institute for Clinical & Experimental Surgery, Saarland University, 66421 Homburg/Saar, Germany

7. Institute for Zoology, Molecular Cell Physiology and Endocrinology, Technical University Dresden, 01062 Dresden, Germany

8. Department of Drug Design and Optimization, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 66123 Saarbrücken, Germany

Funder

Bundesministerium f?r Bildung und Forschung

Deutsche Forschungsgemeinschaft

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.9b00932

Reference34 articles.

1. American Association of Clinical Endocrinologists and American College of Endocrinology Clinical Practice Guidelines for the Diagnosis and Treatment of Postmenopausal Osteoporosis — 2016

2. Estrogens and Androgens in Skeletal Physiology and Pathophysiology

3. Hormone-replacement therapy: current thinking

4. Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy

5. Selective estrogen receptor modulators in clinical practice: a safety overview

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