Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone-Reference-Cited by-同舟云学术

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Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPARγ Drug Pioglitazone

Published:2019-01-24 Issue:4 Volume:62 Page:2008-2023
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Mosure Sarah A.,Shang Jinsai^ORCID,Eberhardt Jerome¹,Brust Richard,Zheng Jie,Griffin Patrick R.^ORCID,Forli Stefano¹^ORCID,Kojetin Douglas J.^ORCID

Affiliation:

1. Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California 92037, United States

Funder

Division of Biological Infrastructure

National Institute of Diabetes and Digestive and Kidney Diseases

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01573

Reference59 articles.

1. Corepressors selectively control the transcriptional activity of PPARγ in adipocytes

2. PPARγ signaling and metabolism: the good, the bad and the future

3. The Nuclear Receptor Superfamily and Drug Discovery

4. The mouse peroxisome proliferator activated receptor recognizes a response element in the 5′ flanking sequence of the rat acyl CoA oxidase gene.

5. The Gene Encoding the Acyl-CoA-binding Protein Is Activated by Peroxisome Proliferator-activated Receptor γ through an Intronic Response Element Functionally Conserved between Humans and Rodents

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