Identification of Dihydrofuro[3,4-d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties-Reference-Cited by-同舟云学术

Identification of Dihydrofuro[3,4-d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties

Published:2019-01-09 Issue:3 Volume:62 Page:1484-1501
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kang Dongwei¹^ORCID,Zhang Heng¹,Wang Zhao¹,Zhao Tong¹,Ginex Tiziana²,Luque Francisco Javier²^ORCID,Yang Yang³,Wu Gaochan¹,Feng Da¹,Wei Fenju¹,Zhang Jian¹^ORCID,De Clercq Erik⁴,Pannecouque Christophe⁴,Chen Chin Ho⁵,Lee Kuo-Hsiung⁶⁷^ORCID,Murugan N. Arul⁸,Steitz Thomas A.³,Zhan Peng¹^ORCID,Liu Xinyong¹

Affiliation:

1. Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Jinan, Shandong, P. R. China

2. Department of Nutrition, Food Science and Gastronomy, Faculty of Pharmacy, Campus Torribera, Institute of Biomedicine (IBUB) and Institute of Theoretical and Computational Chemistry (IQTCUB), University of Barcelona, 08921 Santa Coloma de Gramenet, Spain

3. Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520-8114, United States

4. Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, KU Leuven, Herestraat 49 Postbus 1043 (09.A097), B-3000 Leuven, Belgium

5. Surgical Oncology Research Facility, Duke University Medical Center, Box 2926, Durham, North Carolina 27710, United States

6. Natural Products Research Laboratories, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States

7. Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 40402, Taiwan

8. Department of Theoretical Chemistry and Biology, Royal Institute of Technology (KTH), AlbaNova University Center, S-106 91 Stockholm, Sweden

Funder

Shandong Province

KU Leuven

Ministerio de Economía y Competitividad

National Institute of Allergy and Infectious Diseases

Generalitat de Catalunya

Shandong University

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)