Optimization of Blood–Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold-Reference-Cited by-同舟云学术

Optimization of Blood–Brain Barrier Permeability with Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibitors Having a 2-Aminopyridine Scaffold

Published:2019-02-25 Issue:5 Volume:62 Page:2690-2707
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Do Ha T.¹,Li Huiying²,Chreifi Georges²,Poulos Thomas L.²^ORCID,Silverman Richard B.¹^ORCID

Affiliation:

1. Department of Chemistry, Department of Molecular Biosciences, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Discovery, Center for Developmental Therapeutics, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, United States

2. Departments of Molecular Biology and Biochemistry, Pharmaceutical Sciences, and Chemistry, University of California, Irvine, California 92697-3900, United States

Funder

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b02032

Reference56 articles.

1. The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes

2. CNS drug development in Europe — Past progress and future challenges

3. Demystifying Brain Penetration in Central Nervous System Drug Discovery