Effects of Systematic Shortening of Noncovalent C8 Side Chain on the Cytotoxicity and NF-κB Inhibitory Capacity of Pyrrolobenzodiazepines (PBDs)-Reference-Cited by-同舟云学术

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Effects of Systematic Shortening of Noncovalent C8 Side Chain on the Cytotoxicity and NF-κB Inhibitory Capacity of Pyrrolobenzodiazepines (PBDs)

Published:2019-01-28 Issue:4 Volume:62 Page:2127-2139
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Corcoran David B.¹,Lewis Thomas²,Nahar Kazi S.¹,Jamshidi Shirin¹,Fegan Christopher²,Pepper Chris²³,Thurston David E.¹,Rahman Khondaker Miraz.¹^ORCID

Affiliation:

1. Institute of Pharmaceutical Science, School of Cancer and Pharmaceutical Sciences, King’s College London, London SE1 9NH, U.K.

2. School of Medicine, Cardiff University, Cardiff CF14 4XN, U.K.

3. Brighton and Sussex Medical School, University of Sussex, Brighton BN1 9PX, U.K.

Funder

Worldwide Cancer Research

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01849

Reference39 articles.

1. A quantitative assay to measure the relative DNA-binding affinity of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) antitumour antibiotics based on the inhibition of restriction endonucleaseBamhI

2. Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine−Poly(N-methylpyrrole) Conjugates

3. Inhibition of Bacteriophage T7 RNA Polymerase in Vitro Transcription by DNA-Binding Pyrrolo[2,1-c][1,4]benzodiazepines

4. Biosynthesis, synthesis, and biological activities of pyrrolobenzodiazepines

5. Pyrrolo[1,4]benzodiazepine antitumor antibiotics: relationship of DNA alkylation and sequence specificity to the biological activity of natural and synthetic compounds

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1. Antibody-drug conjugates for targeted cancer therapy: Recent advances in potential payloads;European Journal of Medicinal Chemistry;2024-10

2. Convergent evolution of antibiotic resistance mechanisms between synthetic pyrrolobenzodiazepines (PBDs) and the naturally occurring albicidin in multidrug resistant Klebsiella pneumoniae;2024-09-11

3. Comprehensive review on the elaboration of payloads derived from natural products for antibody-drug conjugates;European Journal of Medicinal Chemistry;2024-03

4. Development of a Novel DNA Mono-alkylator Platform for Antibody–Drug Conjugates;Molecular Cancer Therapeutics;2024-02-13

5. Antibody–drug conjugates: Recent advances in payloads;Acta Pharmaceutica Sinica B;2023-10

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