Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine−Poly(N-methylpyrrole) Conjugates-Reference-Cited by-同舟云学术

Design, Synthesis, and Biophysical and Biological Evaluation of a Series of Pyrrolobenzodiazepine−Poly(N-methylpyrrole) Conjugates

Published:2006-08-05 Issue:18 Volume:49 Page:5442-5461
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wells Geoff¹,Martin Christopher R. H.¹,Howard Philip W.¹,Sands Zara A.¹,Laughton Charles A.¹,Tiberghien Arnaud¹,Woo Chi Kit¹,Masterson Luke A.¹,Stephenson Marissa J.¹,Hartley John A.¹,Jenkins Terence C.¹,Shnyder Steven D.¹,Loadman Paul M.¹,Waring Michael J.¹,Thurston David E.¹

Affiliation:

1. Cancer Research UK Gene Targeted Drug Design Research Group, The School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, U.K., Spirogen Ltd, 2 Royal College Street, London NW1 0NH, U.K., Department of Pharmacology, University of Cambridge, Tennis Court Road, Cambridge CB2 1PD, UK, School of Pharmacy, University of Nottingham, University Park, Nottingham NG7 2RD, U.K., Cancer Research UK Drug-DNA Interactions Research Group, Department of Oncology, Royal Free and University...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm051199z

Reference52 articles.

1. Recognition of the DNA minor groove by pyrrole-imidazole polyamides

2. Accessibility of Nuclear Chromatin by DNA Binding Polyamides

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