Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents-Reference-Cited by-同舟云学术

Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

Published:2018-08-20 Issue:17 Volume:61 Page:7630-7639
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Santoni Gianluca¹²^ORCID,de Sousa Julien³⁴,de la Mora Eugenio¹,Dias José²,Jean Ludovic⁵^ORCID,Sussman Joel L.⁶,Silman Israel⁷,Renard Pierre-Yves⁵,Brown Richard C. D.⁴,Weik Martin¹,Baati Rachid³,Nachon Florian²^ORCID

Affiliation:

1. Université Grenoble Alpes, CEA, CNRS, IBS, F-38000 Grenoble, France

2. Département de Toxicologie et Risques Chimiques, Institut de Recherche Biomédicale des Armées, 91220 Brétigny-sur-Orge, France

3. Université de Strasbourg, ICPEES, UMR CNRS 7515, 67087 Strasbourg, France

4. Department of Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, United Kingdom

5. Université de Normandie, COBRA, UMR 6014, FR 3038, Université de Rouen, INSA de Rouen, CNRS, 76821 Mont-Saint-Aignan, France

6. Department of Structural Biology, Weizmann Institute of Science, 76100 Rehovot, Israel

7. Department of Neurobiology, Weizmann Institute of Science, 76100 Rehovot, Israel

Funder

Agence Nationale de la Recherche

Universit? de Strasbourg

Minist?re de la D?fense

Direction G?n?rale de l?Armement

University of Southampton

Defence Science and Technology Laboratory

Centre National de la Recherche Scientifique

Service de Sant? des Arm?es

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00592

Reference40 articles.

1. Acetylcholinesterase: ‘classical’ and ‘non-classical’ functions and pharmacology

2. Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents

3. Development and Structural Modifications of Cholinesterase Reactivators against Chemical Warfare Agents in Last Decade: A Review

4. Kinetic analysis of interactions between human acetylcholinesterase, structurally different organophosphorus compounds and oximes

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