Novel uncharged triazole salicylaldoxime derivatives as potential acetylcholinesterase reactivators: comprehensive computational study, synthesis and <i>in vitro</i> evaluation-Reference-Cited by-同舟云学术

Novel uncharged triazole salicylaldoxime derivatives as potential acetylcholinesterase reactivators: comprehensive computational study, synthesis and in vitro evaluation

Published:2023 Issue:41 Volume:13 Page:28527-28541
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Baghersad Mohammad Hadi¹^ORCID,Habibi Azizollah²^ORCID,Dehdashti nejad Arash¹

Affiliation:

1. Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran

2. Faculty of Chemistry, Kharazmi University, No. 43, P. Code 15719-14911, Mofatteh Street, Enghelab Ave., Tehran, Iran

Abstract

We design and synthesis new aldoximes without charge and test their reactivation, structure, and action of paraoxon-blocked acetylcholinesterase using calculations and experiments.

Funder

Baqiyatallah University of Medical Sciences

Publisher

Royal Society of Chemistry (RSC)

Subject

General Chemical Engineering,General Chemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2023/RA/D3RA05658A

Reference60 articles.

1. Nerve Agents: What They Are, How They Work, How to Counter Them

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4. Review about Structure and Evaluation of Reactivators of Acetylcholinesterase Inhibited with Neurotoxic Organophosphorus Compounds

5. Management of acute organophosphorus pesticide poisoning

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