Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) β Inhibitor
Author:
Affiliation:
1. Gilead Sciences, Inc., 199 East Blaine Street, Seattle, Washington 98102, United States
2. Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, California 94404, United States
Funder
Biological and Environmental Research
National Institute of General Medical Sciences
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b00797
Reference39 articles.
1. Nonbiaryl and Heterobiaryl Atropisomers: Molecular Templates with Promise for Atropselective Chemical Transformations
2. A twist of nature – the significance of atropisomers in biological systems
3. Atroposelective Synthesis of Axially Chiral Biaryl Compounds
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