Discovery of an Orally Available Janus Kinase 3 Selective Covalent Inhibitor-Reference-Cited by-同舟云学术

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Discovery of an Orally Available Janus Kinase 3 Selective Covalent Inhibitor

Published:2019-01-07 Issue:2 Volume:62 Page:1054-1066
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Shi Liyang¹,Zhong Zhenpeng¹,Li Xitao¹,Zhou Yiqing¹^ORCID,Pan Zhengying¹^ORCID

Affiliation:

1. State Key Laboratory of Chemical Oncogenomics, Engineering Laboratory for Chiral Drug Synthesis, Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School, Peking University, Shenzhen 518055, China

Funder

Ministry of Science and Technology of the People's Republic of China

Shenzhen Municipal Development and Reform Commission

Shenzhen Science and Technology Innovation Commission

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.8b01823

Reference20 articles.

1. Discovery and Development of Janus Kinase (JAK) Inhibitors for Inflammatory Diseases

2. A new modality for immunosuppression: targeting the JAK/STAT pathway

3. Discovery of CP-690,550: A Potent and Selective Janus Kinase (JAK) Inhibitor for the Treatment of Autoimmune Diseases and Organ Transplant Rejection

4. Identification of a Potent Janus Kinase 3 Inhibitor with High Selectivity within the Janus Kinase Family

5. Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans

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1. Recent advances in the design of small molecular drugs with acrylamides covalent warheads;Bioorganic & Medicinal Chemistry;2024-10

2. Identification of novel covalent JAK3 inhibitors through consensus scoring virtual screening: integration of common feature pharmacophore and covalent docking;Molecular Diversity;2024-07-15

3. Design, synthesis and biological evaluation of structurally new 4-indolyl quinazoline derivatives as highly potent, selective and orally bioavailable EGFR inhibitors;Bioorganic Chemistry;2024-01

4. Docking and Selectivity Studies of Covalently Bound Janus Kinase 3 Inhibitors;International Journal of Molecular Sciences;2023-03-23

5. Covalent Modification of the JH2 Domain of Janus Kinase 2;ACS Medicinal Chemistry Letters;2022-10-24

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